The trail is paved, in good condition, and is mostly flat until the final 5 miles or so into Harmony (between County Road 16 and Harmony) where some steep roller coaster type hills take you alongside the edges of agricultural fields and through small woodlots as the trail makes its way from the river valley and climbs up to Harmony. The Harmony-Preston State Trail is popular with cyclists, hikers, and skaters. In the winter, the trail is groomed for cross country skiers.
Trailheads are available in Preston using US 52 to Fillmore Street/County 12, and drive a half mile to the lot. In Harmony, you can park at the tourist center at the end of 2nd Street NW at Main Street, or take US 52 to 4th Street NW, west to the lot.